Molecular cytogenetics: recent developments and applications in cancer.

Cytoplasmic Her2/neu immunohistochemical staining in breast cancer; From a molecular point of view

Targeted Cancer Diagnostic and Therapeutic Agents: Delivery by Carriers or Conjugation

Receptors and proteins are overexpressed in many human cancer cell membranes rather than normal tissues and are considered as the main molecular targets. Specific tumor- targeting molecules which have high affinity for these receptors can be valuable tools as carrier molecules for targeted cancer therapy and imaging. Pharmacokinetics and bioavailability of diagnostic and therapeutic agents are ...

An Overview of Technological Developments in Medical Applications of X-Rays and Radioactivity

The years 1895 to 1898 were momentous for their impact on health and human well beings. First, Wilhelm Roentgen noted a glowing fluorescent screen, caused by invisible rays. This event subsequently led to the discovery of X-rays in 1895, and thus the birth of the “atomic age”. Next Becquerel’s investigations of these mysterious rays led to his experiments with uranium salt crystals. He th...

Molecular diagnosis in female genital tract tumors: Presentation of interesting cases

Introduction Recent developments in molecular cytogenetics and molecular cell biology have born fruits as new medical strategies. In the field of diagnostic surgical pathology, the introduction of so-called molecular diagnostics appears to be based on such trends. Although most female genital tract tumors have not fully been studied molecular-cytogenetically, the concept, nomenclature, and the ...

Diagnosis and Disease Management in CML Patients Using Conventional and Molecular Cytogenetics

Chronic Myeloid Leukemia (CML) is a hematopoietic malignancy characterized by the presence ofPhiladelphia (Ph1) chromosome that results from balanced reciprocal translocation between chromosomes9 and 22 leading in the formation of bcr/abl fusion gene. The present study was conducted to evaluate cytogenetic and molecular abnormalities in CML patients at presentation and during the co...